Consensus 3D Model of μ-Opioid Receptor Ligand Efficacy Based on a Quantitative Conformationally Sampled Pharmacophore
نویسندگان
چکیده
منابع مشابه
A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids
Background Opioid receptors belong to the rhodopsin subclass within the superfamily of G protein-coupled receptors (GPCR), which are characterized by the presence of seven transmembrane (7TM) helices. They interact with morphine and related opioid alkaloids as well as with endogenous opioid peptides. There are three main types of opioid receptors (μ, δ, ), which are differently implicated in op...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2011
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp202542g